Progenitor mast cells and tryptase in Q fever |
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| Affiliation: | 1. Aix-Marseille Univ, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France;2. Department of Epidemiology and Health Economics, Aix-Marseille Univ, Marseille, France;3. APHM, IHU Méditerranée Infection, UF Immunologie, Marseille, France;1. Depatment of Zoonoses, Faculty of Veterinary Medicine, Zagazig University, 44511, Zagazig, Egypt;2. Department of Virology, Faculty of Veterinary Medicine, Zagazig University, 44511, Zagazig, Egypt;3. The United Graduate School of Veterinary Science, Yamaguchi University, 16771-1 Yoshida, Yamaguchi-shi, 753-8515, Japan;1. Universidade Federal Fluminense, Departamento de Microbiologia e Parasitologia, Laboratório de Bacteriologia Veterinária, Rua Professor Hernani Melo 101, Niterói, 24210-130, Brazil;2. Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Laboratório de Epidemiologia Molecular e Resistência a Antimicrobianos, Av. Prof. Orlando Marques de Paiva 87, São Paulo, 05508-010, Brazil;3. Universidade Federal de Pelotas, Núcleo de Biotecnologia, Centro de Desenvolvimento Tecnológico, Rua Gomes Carneiro 1, Pelotas, 96010-610, Brazil;1. Department of Animal Management, College of Veterinary Science and Medicine, Central Luzon State University, Science City of Muñoz 3120, Nueva Ecija, Philippines;2. Biosafety and Environment Section, Philippine Carabao Center National Headquarters and Gene Pool, Science City of Muñoz 3120, Nueva Ecija, Philippines;3. Department of Biological Sciences, College of Arts and Sciences, Central Luzon State University, Science City of Muñoz 3120, Nueva Ecija, Philippines;4. Department of Animal Science, College of Agriculture, Central Luzon State University, Science City of Muñoz 3120, Nueva Ecija, Philippines;1. Laboratory of Theoretical Spectroscopy, V.E. Zuev Institute of Atmospheric Optics SB RAS, 1, Academician Zuev square, Tomsk 634021, Russia;2. Laboratory of Quantum Mechanics of Molecules and Radiative Processes, Tomsk State University, 36 Lenin Avenue, 634050 Tomsk, Russia;3. Université Grenoble Alpes, LIPhy, F-38000 Grenoble, France;4. CNRS, LIPhy, F-38000 Grenoble, France;5. Groupe de Spectrométrie Moléculaire et Atmosphérique, UMR CNRS 7331, UFR Sciences Exactes et Naturelles, BP 1039-51687 Reims Cedex 2, France |
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| Abstract: | Q fever is an infectious disease due to Coxiella burnetii. Following a primary-infection, C. burnetii may persist in some patients, leading to endocarditis and vascular infections. Mast cells (MCs), known for their role in allergic diseases, innate immunity and cardiac function, are produced by bone marrow, circulate as progenitors in the bloodstream and reach tissues for their maturation and activation. The latter may be estimated by measuring serum tryptase levels. We wondered if MC progenitors and tryptase were affected in Q fever. We showed a decrease in MC progenitor count in Q fever patients whereas serum tryptase levels were increased. Taken together, our results show alterations of MC numbers and activity in Q fever patients, suggesting that MC are involved in Q fever pathophysiology. |
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| Keywords: | Mast cells progenitors Tryptase Q fever Flow cytometry |
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