Duck circovirus induces a new pathogenetic characteristic,primary sclerosing cholangitis |
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| Affiliation: | 1. College of Veterinary Medicine, Shandong Agricultural University, Tai’an, 271018, PR China;2. Qindao husbandry and Veterinary Institute, Qingdao, 266000, PR China;1. College of Veterinary Medicine, Shandong Agricultural University, Tai`an, 271018, China;2. Qingdao Husbandry and Veterinary Institute, Qingdao, 266000, China;3. Department of Animal Science and Technology, Vocational-technical School of Husbandry and Veterinary Medicine, Weifang, 261061, China;1. College of Agriculture and Forestry, Linyi University, Shuangling Road, Linyi City, Shandong, 276005, PR China;2. Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No. 518, Ziyue Road, Shanghai, 200241, PR China;3. Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, Taian, Shandong, 271018, PR China;4. College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, No. 90, Hualan Street, Xinxiang, 453003, Henan, PR China;1. College of Agriculture and Forestry Science, Linyi University, Shuangling Road, Linyi City, Shandong, 276005, PR China;2. Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No. 518, Ziyue road, Shanghai, 200241, PR China;3. Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, Taian, Shandong, 271018, PR China;1. Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China;2. Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China;3. Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, 611130, China;1. State Forestry Administration Key Laboratory of Wildlife Conservation, College of Wildlife Resources, Northeast Forestry University, Harbin 150040, China;2. College of Basic Medical Science, Heilongjiang University of Chinese Medicine, Harbin, 150040, China |
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| Abstract: | Primary sclerosing cholangitis (PSC) is a chronic, cholestatic liver disease of unknown cause. In the study, we found that duck circovirus (DuCV) induces PSC in natural and reproductive cases. PSC in DuCV naturally infected ducks was investigated by PCR and histopathology. A model of PSC was developed in one-day old duck by infection of DuCV. Effects on serum levels of liver enzymes and histology were evaluated, and DuCV tropism for bile duct in liver was analyzed by immuohistochemistry. Pathology observation of natural or reproductive DuCV infected ducks showed that the lesion of liver were characterized by cholangiocytic injuries and progressive fibrous obliteration of the biliary tree associated with lymphocytes infiltration. ALT, AST, ALP, GGT, ALB, TBIL and TP were significantly increased in serum of DuCV infected ducks. DuCV showed higher tropism for epithelial cells of bile duct than other cells in PSC. |
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| Keywords: | Primary sclerosing cholangitis Duck circovirus Pathology Serum biochemistry Immunohistochemistry |
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