Staphylococcus aureus intra-mammary infection affects the expression pattern of IL-R8 in goat |
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Affiliation: | 1. Institute of Physiology II, University of Münster, Robert-Koch Str. 27b, 48149 Münster, Germany;2. Institute of Medical Microbiology, University of Münster, Domagkstr.10, 48149 Münster, Germany |
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Abstract: | IL-1R8 is a member of Interleukin-1 receptor family acting as a negative regulator of inflammation reliant on ILRs and TLRs activation. IL-1R8 role has never been evaluated in acute bacterial mastitis. We first investigated IL-1R8 sequence conservation among different species and its pattern of expression in a wide panel of organs from healthy goats. Then, modulation of IL-1R8 during natural and experimental mammary infection was evaluated and compared in blood, milk and mammary tissues from healthy and Staphylococcus aureus infected goats. IL-1R8 has a highly conserved sequence among vertebrates. Goat IL-1R8 was ubiquitously expressed in epithelial and lymphoid tissues with highest levels in pancreas. IL-1R8 was down-regulated in epithelial mammary cells following S. aureus infection. Interestingly it was up-regulated in leukocytes infiltrating the infected mammary tissues suggesting that it could represent a target of S. aureus immune evasion. |
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Keywords: | IL-1R8/TIR8/SIGIRR Intra-mammary infection Goat Innate immunity |
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