Anti-inflammatory and cytotoxic 2-arylbenzofurans from Morus wittiorum |
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| Authors: | Tan Yong-Xia Wang Hong-Qing Chen Ruo-Yun |
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| Affiliation: | Department of Medicinal Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, PR China. |
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| Abstract: | Three new 2-arylbenzofurans named wittifuran H, wittifuran I and wittifuran U (1-3) were obtained during our ongoing investigation of an ethanol extract from the stem bark of Morus wittiorum. Their structures were elucidated on the basis of spectroscopic data. Compound 2 displayed potent anti-inflammatory activity and selective cytotoxicity against human gastric cancer cell line BGC-823 with an IC(50) value of 1.45μM. |
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| Keywords: | Morus wittiorum Moraceae 2-arylbenzofuran Anti-inflammation Cytotoxicity |
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