Effect of ischemic preconditioning on vascular reactivity and calcium sensitivity in hemorrhagic shock rats |
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Authors: | HU Yi LI Tao XU Jing TANG Xiao-feng LIU Liang-ming |
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Institution: | 1.Department of Anesthesiology, ;2.State Key Laboratory of Trauma, Burns and Combined Injury, Department 2, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China. E-mail: liangmingliu@yahoo.com |
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Abstract: | AIM: To investigate the effect of ischemic preconditioning (IPC) on vascular reactivity and calcium sensitivity during hemorrhagic shock. METHODS: Appropriate method of IPC was selected by observing the effect of different strategies of IPC on the survival time and the survival rate in hemorrhagic shock rats. The effect of IPC on the pressor effect of norepinephrine (NE, 3 μg/kg) and the contractile response of superior mesenteric artery (SMA) to NE and calcium in vivo and in vitro were observed. RESULTS: Among 3 strategies of IPC, 3 cycles of abdominal aorta occlusion for 1 min and loosing for 5 min increased the survival time and 24 h survival rate significantly, which was superior to the other two IPC methods. In vivo, IPC significantly increased the pressor response to NE and the contractile response of SMA to NE (P<0.01). In vitro, IPC significantly improved the reactivity of SMA to NE and Ca2+. The Emax values of SMA to NE and Ca2+ in IPC group were significantly higher than that in shock control group (P<0.01). CONCLUSION: Ischemic preconditioning reverses Shock-induced vascular hyporeactivity via improving calcium sensitivity of the vasculatures. |
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Keywords: | Ischemic preconditioning Shock hemorrhagic Vascular reactivity Calcium sensitivity |
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