Sensitivity,specificity and ROC curve analysis of echocardiography for diagnosis of coronary artery disease

AIM: To analyze the sensitivity, specificity and receiver operating characteristic (ROC) curve of echocardiography for diagnosis of coronary artery disease. METHODS: One hundred and fourteen subjects were selected according to the clinical diagnostic criteria of coronary artery disease and echocardiography was performed. The regional ventricular wall motion was observed, and the left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left ventricular ejection fraction and the ratio of early-diastolic peak flow velocity to late-diastolic peak flow velocity were measured in all subjects. The coronary angiography was performed, and the final diagnosis of coronary artery disease was made when the degree of the coronary artery stenosis was ≥50%. RESULTS: The final diagnosis of coronary artery disease was confirmed by coronary angiography in 96 cases of the total 114 patients selected. Among them, attenuation, disappearance and paradoxical motion of the regional ventricular wall motion were observed, and a sensitivity of 79.2% and a positioning accuracy of 75.0% were achieved by echocardiography. The sensitivity was 82.2% and the specificity was 100% when the score of the regional left ventricular wall motion was divided into the cut-off point of ≥4, and the area under the ROC curve was 0.95 (0.89-0.98). CONCLUSION: Echocardiography is a preferred non-invasive method for diagnosis of coronary artery disease. The score of regional ventricular wall motion has high specificity and sensitivity in the diagnosis of coronary artery disease.