Formation and activity of lymphocyte-derived microparticles |
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| Authors: | QIU Qian ZHAO Ling XIONG Wei |
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| Institution: | 1. Respiration Department of Southwest Hospital Affiliated to The Third Military Medical University, Chongqing 400038, China;
2. Department of Obstetrics and Gynecology, The Twelfth Hospital of PLA, Kashi 830000, China |
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| Abstract: | Lymphocyte-derived microparticles (LMPs) are small membrane vesicles that are released upon activation or during apoptosis from lymphocytes.The LMPs were detected at elevated levels in the patients with inflammatory diseases, cardiovascular diseases or diabetes. In addition, LMPs are important mediators of transferring biological information and switching on the biological effects through their interaction with the target cells. Moreover, LMPs play completely distinct roles in different physiological and pathological conditions. This article describes the possible mechanism involved in the formation, composition, key biological activities and the relationship with diseases. |
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| Keywords: | Lymphocyte-derived microparticles Immune response Angiogenesis |
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