鱼类无乳链球菌病的研究进展

无乳链球菌是常见的人兽共患病原菌，常导致新生儿肺炎、脑膜炎、败血症及奶牛乳腺炎。近年来，在水生动物体内也频繁分离到该菌，尤其是自2007年以来，该菌每年都在中国广东、海南、福建、广西等罗非鱼主要养殖区暴发流行，严重威胁着罗非鱼养殖业的健康发展。作者综述了当前国内外对鱼类无乳链球菌病的病原学、流行病学、症状、病理变化、毒力因子（荚膜多糖、CAMP因子、表面免疫原性蛋白、α蛋白、C5a肽酶）和防控等方面的研究进展，以期为中国鱼类无乳链球菌病的防控提供参考。

Research Progress on Fish Streptococcus agalactiae Disease

Streptococcus agalactiae is common zoonotic bacteria,which cause neonatal pneumonia,meningitis,septicemia and mastitis in dairy cows.In recent years,it was also be isolated from aquatic animals frequently.Especially since 2007,diseases caused by the bacteria outbreak in Guangdong,Hainan,Fujian,Guangxi and other tilapia aquaculture areas and had a serious threat to the healthy development of tilapia aquaculture in china.In this paper, research progresses on fish Streptococcus agalactiae disease were reviewed.The etiology,epidemiology,symptoms,pathological changes,virulence factors (capsular polysaccharide,CAMP factor,Sip,protein alpha,C5a peptidase) and prevention and control were included in the review,which would provide references for the fish Streptococcus agalactiae disease prevention and control.