猪繁殖与呼吸综合征病毒非结构蛋白研究进展

猪繁殖与呼吸综合征（porcine reproductive and respiratory syndrome, PRRS）是一种遍布于全世界的高度传染性疾病，其病原是猪繁殖与呼吸综合征病毒（porcine reproductive and respiratory syndrome virus, PRRSV）。感染PRRSV后，最先在机体内进行表达的是非结构蛋白（nonstructural proteins, NSPs），PRRSV基因组编码区经翻译后至少产生14种NSPs（NSP1α、NSP1β、NSP2、NSP3、NSP4、NSP5、NSP6、NSP7a、NSP7b、NSP8、NSP9、NSP10、NSP11、NSP12），这些NSPs在病毒增殖、病毒毒力、免疫学特性等方面都发挥着重要作用。作者就NSPs的研究进展进行简要概述，以期为PRRS疫苗研发及技术防控奠定基础。

Research Progress on the Nonstructural Proteins of Porcine Reproductive and Respiratory Syndrome Virus

Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious disease that spreads all over the world.It is caused by porcine reproductive and respiratory syndrome virus (PRRSV).Once infected with PRRSV,NSPs (nonstructural proteins) were expressed firstly.At least 14 kinds of NSPs,including NSP1α,NSP1β,NSP2,NSP3,NSP4,NSP5,NSP6,NSP7a,NSP7b,NSP8,NSP9,NSP10,NSP11 and NSP12,were produced during PRRSV life,which plays an important role in virus proliferation,virus virulence,immunological characteristics and so on.In this paper,we make a brief overview in terms of the research progress on NSPs to make a basis for the prevention of PRRS.