猪圆环病毒2型基因组DNA的结构与功能研究进展

猪圆环病毒2型(PCV2)是引起猪圆环病毒病相关疾病的主要致病原,可损伤宿主的免疫系统,加剧一些细菌病和病毒病感染的临床症状,在全球养猪业中造成巨大损失。PCV2的基因组DNA含有11个开放阅读框(ORFs),其中至少有7个ORFs编码的蛋白质分子质量大于5ku,但目前只有5种编码的蛋白(Rep、Rep'、Cap、ORF3和ORF4)发现于PCV2复制过程中。作者概述了当前PCV2基因组DNA的结构与功能,阐明PCV2的病原学,为防控PCV2感染提供科学依据。

Advances on Structure and Function of Genomic DNA of Porcine Circovirus Type 2

Porcine circovirus type 2 (PCV2) is a disease caused by porcine circovirus, which can damage the host's immune system and exacerbate the clinical symptoms of many bacterial and viral infections.It has caused increasingly larger losses in the pig industry wordwide.The genomic DNA of PCV2 contains 11 open reading frames (ORFs) and at least seven potential ORFs-encoding proteins larger than 5 ku.However, only five virally encoded proteins, including Rep, Rep', Cap, ORF3 and ORF4, had been identified in PCV2 replication.In this review, we discussed the progress on structure and function of genomic DNA of PCV2 in order to provide insight into the scientific basis of the pathogenesis of PCV2 and prevent its infection.