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| 低聚糖硫酸酯及右旋糖酐硫酸酯对临床型奶牛乳房炎治疗效果的研究 | |
| 引用本文： | 张哲,李新圃,杨峰,罗金印,刘龙海,李宏胜.低聚糖硫酸酯及右旋糖酐硫酸酯对临床型奶牛乳房炎治疗效果的研究[J].中国畜牧兽医,2016,43(7):1799-1804. |
| 作者姓名： | 张哲 李新圃 杨峰 罗金印 刘龙海 李宏胜 |
| 作者单位： | 1. 甘肃农业大学动物医学院, 兰州 730070; 2. 中国农业科学院, 兰州畜牧与兽药研究所/农业部兽 用药物创制重点实验室, 甘肃省新兽药工程重点实验室, 兰州 730050 |
| 基金项目： | "十二五"国家科技支撑项目（2012BAD12B00）；甘肃省科技支撑计划（144NKCA240）；甘肃省农业科技创新项目（GNCX-2013-59）；甘肃省农业生物技术研究与应用开发项目（GNSW-2013-28）；中国农业科学院奶牛疾病研究创新团队项目 |
| 摘 要： | 为探究低聚糖硫酸酯（DEAE）及右旋糖酐硫酸酯（DS-4000）对临床型奶牛乳房炎的治疗效果，将56头患临床型乳房炎奶牛随机分为5组（DEAE组、DS-4000组、DEAE＋青霉素组、DS-4000＋青霉素组及青霉素对照组），进行药物乳房灌注治疗，每天2次，连用3 d，并在治疗前后分别采集奶样进行细菌学检测。临床观察统计各治疗组有效率，细菌检测统计细菌转阴率。结果显示，奶牛乳房灌注DEAE、DS-4000、DEAE＋青霉素、DS-4000＋青霉素及青霉素进行治疗3 d后，总有效率分别为：10.00%、20.00%、58.33%、75.00%和50.00%；乳汁细菌转阴率分别为：0、12.50%、50.00%、54.55%和44.44%。结果表明，DEAE及DS-4000对临床型奶牛乳房炎有一定的治疗作用，但效果不理想，与青霉素联用可以增强抗生素的疗效。 |
| 关 键 词： | 低聚糖硫酸酯 右旋糖酐硫酸酯 青霉素 奶牛乳房炎 治疗效果 |
| 收稿时间： | 2015-12-07 |
Study on Clinical Efficacy of Oligosaccharide Sulfate and Dextran Sulfate Against Bovine Mastitis |
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| ZHANG Zhe,LI Xin-pu,YANG Feng,LUO Jin-yin,LIU Long-hai,LI Hong-sheng.Study on Clinical Efficacy of Oligosaccharide Sulfate and Dextran Sulfate Against Bovine Mastitis[J].China Animal Husbandry & Veterinary Medicine,2016,43(7):1799-1804. | |
| Authors: | ZHANG Zhe LI Xin-pu YANG Feng LUO Jin-yin LIU Long-hai LI Hong-sheng |
| Institution: | 1. College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China; 2. Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Discovery, Ministry of Agriculture, Lanzhou Institute of Animal Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China |
| Abstract: | In order to detect the clinical efficacy of oligosaccharide sulfate(DEAE) and dextran sulfate (DS-4000) against bovine mastitis,56 cows with bovine mastitis were divided into 5 groups (DEAE group,DS-4000 group,DEAE＋penicillin group,DS-4000＋penicillin group and penicillin group),and their breasts were perfusion with different drugs twice one day for 3 days.The effective rates of drugs were observed by clinic symptoms.Milk samples were collected before and after treatment of drugs,and the bacterial negative conversion rate of each group were detected by microbial examination.The results showed that total effective rates of 5 groups were 10.00%,20.00%,58.33%,75.00% and 50.00%,respectively,and the bacterial negative conversion rates were 0,12.50%,50.00%,54.55% and 44.44%,respectively.In conclusion,the curative efficiencies of the polysaccharides against bovine mastitis were weak,but it could be improved by combination with penicillin. |
| Keywords: | DEAE DS-4000 penicillin bovine mastitis therapeutic effect |
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