Antimicrobial activity of 2-arylbenzofurans from Morus species against methicillin-resistant Staphylococcus aureus |
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| Authors: | Fukai Toshio Kaitou Kiyoshi Terada Sumio |
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| Institution: | aSchool of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan;bResearch Laboratory, Zenyaku Kogyo Co., Ltd., 2-33-7 Oizumi, Nerima-ku, Tokyo 178-0062, Japan |
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| Abstract: | Nine 2-arylbenzofurans isolated from Morus species were tested for their antimicrobial activities against methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA), Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. Among these compounds, chalcomoracin (a leaf phytoalexine of mulberry tree) exhibited considerable antibacterial activity against MRSAs (MICs 0.78 μg/ml). |
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| Keywords: | Morus Antimicrobial activity MRSA 2-Arylbenzofurans |
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