| 灭活后无血凝价的禽流感H_5亚型病毒的免疫原性研究 |
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| 引用本文： | 颜世敢,任素芳,崔道石,胡北侠,黄艳艳,吴家强.灭活后无血凝价的禽流感H_5亚型病毒的免疫原性研究[J].山东农业科学,2004(5):62-63. |
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| 作者姓名： | 颜世敢 任素芳 崔道石 胡北侠 黄艳艳 吴家强 |
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| 作者单位： | 1. 山东省农业科学院畜牧兽医研究所,山东,济南,250100
2. 齐鲁动物保健品厂,山东,济南,250100 |
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| 摘 要： | 0. 4 %甲醛灭活后血凝价为 0的 2株禽流感H5亚型病毒制备的油乳剂疫苗免疫 14 0日龄蛋鸡 ,疫苗免疫 10天后HI抗体水平分别升到 8. 0Log2、6 . 2Log2以上 ,免疫后 17～ 2 4天HI抗体水平升到高峰 (8. 8Log2、7. 8Log2 ) ,免疫 38天后能抵御剂量为 4ELD50 的同种强毒的攻击。结果表明 ,灭活后血凝价为 0的禽流感H5亚型病毒与灭活后血凝价为 5的病毒抗原的免疫原性无显著差异
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| 关 键 词： | 禽流感 H5亚型 血凝价 免疫原性 |
| 文章编号： | 1001-4942(2004)05-0062-02 |
| 修稿时间： | 2004年4月16日 |
Study on immunogenic of zero - hemocoagulate - value H5 subtype of avian influenza virus |
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| YAN Shi-gan,REN Su-fang,CUI Dao-shi,HU Bei-xia,HUANG Yan-yan,WU Jia-qiang.Study on immunogenic of zero - hemocoagulate - value H5 subtype of avian influenza virus[J].Shandong Agricultural Sciences,2004(5):62-63. |
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| Authors: | YAN Shi-gan REN Su-fang CUI Dao-shi HU Bei-xia HUANG Yan-yan WU Jia-qiang |
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| Institution: | YAN Shi-gan~1,REN Su-fang~1,CUI Dao-shi~2,HU Bei-xia~1,HUANG Yan-yan~1,WU Jia-qiang~1 |
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| Abstract: | Hemocoagulate value of two strains of H_5 subtype of avian Influenza virus decreased to zero when they were inactived by 0.4% formalin, by use of them to prepare oil-vaccine, and immunized 140 days-aged hens, 10 days later HI antibodies values increased to 8.0Log2、6.0Log2, 17～24 days later the value rised to the peak value(8.8Log2、7.8Log2). The tested hens can stand the same viruluent virus attack after 38 days since vaccinization. The result reveal that immunogenic character of zero-hemocoagulate-value and 5-Hemocoagulate-value H_5 subtype of avian influenza virus had no significant difference. |
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| Keywords: | Avian influenza virus H_5 subtype hemocoagulate value immunogenic |
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