诱导多能干细胞技术在猪转基因研究中的应用前景

长期以来,猪都是科学研究中重要的生物模型,转基因猪在生物模型、器官移植和动物良种繁育等方面有着极其重要的研究及应用价值,而现在的转基因克隆猪的成功率及成活率都普遍偏低。诱导多能干细胞技术在再生医学和畜牧业等领域有着广泛而诱人的应用前景,但目前还较少被应用于转基因猪的研究中。作者对转基因技术和诱导多能干细胞技术的发展历程,特别是诱导多能干细胞技术在猪转基因研究中的应用进行简述,以期为开展相关研究的科研人员提供一定的参考。

The Application Prospect of Induced Pluripotent Stem Cells in Pig Transgenic Research

Pig has been an important biologic model of scientific research over the years. Transgenic pigs also have extremely important effects in biologic model, organ transplantation, animal breed breeding, and so on. There are several problems for the transgenic cloned pigs, such as low successful rate and live rate. The induced pluripotent stem cells (iPSCs) technology has wide and amazing application in regenerative medicine and animal husbandry while this technology has not deeply used in pig transgenic research. Here, we briefly review the transgenic technology, iPSCs technology, and the application of the iPSCs technology in the researches of transgenic cloned pigs for providing some references for researchers working in the fields.