Histone deacetylase SIRT1 and cell autophagy |
| |
Authors: | YU Xiao-yan ZHANG Yan-lin CAO Yong-jun LIU Chun-feng |
| |
Institution: | 1.Department of Neurology,Second Affiliated Hospital, 2Institute of Neuroscience,Soochow University, Suzhou 215004,China. |
| |
Abstract: | .Sirtuin 1 (SIRT1), one of the nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases, plays an important role in regulating cell cycle, cell aging, apoptosis and metabolism. Autophagy, a vital basic phenomenon that wildly exists in eukaryotic cells, plays an important part in waste scavenging, structure reestablishment, growth and development. In recent years, more and more attention has been paid to the connection between SIRT1 and autophagy. Clarifying the relationship between SIRT1 and autophagy will be of great importance in preventing and controlling aging-related diseases. This article overviews its research advancement. |
| |
Keywords: | SIRT1 protein Autophagy Aging |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
| 点击此处可从《园艺学报》下载免费的PDF全文 |
|