Effect of Ruanmaijiangzhi mixture intervention on endothelial cell function after artery bypass graft |
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| Authors: | XU Ping PENG Hui ZHU Ying HE Song-min FENG Bing LI Xiu-li HUANG Xiao-qian CHEN Ting ZHANG Xiao-ning ZHENG Guang-juan |
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| Institution: | 1.Guangdong Cardiovascular Institute,2Guangdong General Hospital, Guangzhou 510080, China;3.Guangdong Hospital of Traditional Chinese Medicine, 4Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, China;5.Shandong University of Traditional Chinese Medicine, Jinan 250355, China;6.Guangzhou University of Traditional Chinese Medicine, Guangzhou 510006, China;7.Anhui Provincial Friendship Hospital, Hefei 230041, China. |
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| Abstract: | AIM： To observe the effect of Ruanmaijiangzhi mixture on the function of endothelial cells in rabbits after artery bypass graft. METHODS：A New Zealand white rabbit model of right common carotid artery bypass graft was established. The rabbits were randomly divided into 4 groups： model group, aspirin control group, middle dose of Ruanmaijiangzhi group and high dose of Ruanmaijiangzhi group. Eight weeks after treatment, circulating endothelial cells (CECs) in anticoagulated blood were detected by flow cytometry. The serum levels of P-selectin and intercellular adhesion molecule 1 (ICAM-1) were measured by ELISA. RESULTS：Compared with model group, the relative ratio of CECs, and the levels of P-selectin and ICAM-1 in medication administration groups were significantly decreased. The effect in Ruanmaijiangzhi groups was better than that in aspirin control group. Ruanmaijiangzhi treatment showed a positive dose-related correlation. CONCLUSION：Chinese medicine Ruanmaijiangzhi mixture decreases CECs, P-selectin and ICAM-1 to improve the endothelial cell function after coronary artery bypass graft. |
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| Keywords: | Ruanmaijiangzhi mixture Artery bypass graft Endothelial cells |
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