Expression of macrophage migration-inhibitory factor in human recurrent cervical cancer tissues and its prognostic significance

AIM：To investigate the expression of macrophage migration-inhibitory factor (MIF) in human recurrent cervical cancer tissues and its influence on prognosis. METHODS：Eight-seven cases of recurrent cervical cancer were collected from January 2007 to December 2009 and followed up for at least 36 months. The MIF expression in cervical cancer tissues was tested by immunochemistry. RESULTS：The positive rate of MIF expression in recurrent cervical cancer was 75.7% (55/87). Compared with the patients with negative MIF expression, the patients with positive MIF expression showed worse response to antitumor therapy ［47.3% (26/55) vs 63.6% (21/32), P<0.05］ and shorter survival time (28.8 months vs 38.4 months, P<0.05). CONCLUSION：Positive MIF expression could be a risk factor in recurrence and prognosis of cervical cancer.