类噻唑烷酮离子阻断剂药物毒理学安全性评价

本研究对实验室合成的一种用于治疗动物腹泻的药物囊性纤维化跨膜传导调节因子(cystic fibrosis transmembrane conductance regulator,CFTR)抑制剂——类噻唑烷酮进行了毒理学安全性评价。将受试物通过灌胃给予试验动物,通过全身毒性试验、小鼠精子致变试验、小鼠骨髓嗜多染红细胞微核试验和Ames试验进行安全性评价。结果显示,受试物没有全身急性毒性;在体内没有对生殖细胞致突变作用;不会对染色体和细胞有丝分裂造成损伤;没有诱变性。本研究为进一步将该类噻唑烷酮应用于治疗仔猪腹泻提供可靠的试验依据。

The Toxicological Safety Assessment of Thiazlidone-like Channel Blocker Drug

It was reported that the toxicological safety assessment of a CFTR inhibitor.It was about thiazlidone-like channel blocker drug which synthesized in laboratory, and used in the treatment of animals diarrhea.Drug was given to mice by intragastric administration.Toxicological assessment test of thiazlidone-like channel blocker drug inclued systemic toxicity test,mouse sperm malformation test,bone marrow micronucleus test and Ames test. Results showed that the drug had no acute systemic toxicity, no mutagenic action on germ cells in vivo, no damage on chromosomes and cell mitosis and no mutagenicity. Results provided reliable test basis to use the drug further which could be used to treat diarrhea of piglets.