| 糖原合成激酶抑制剂在胚胎干细胞自我更新中的作用 |
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| 引用本文： | 劳艳萍,柯浩,孙洪亮,刘荣立,马玉洁,阮秋燕,雷钏,陆凤花,李湘萍,石德顺. 糖原合成激酶抑制剂在胚胎干细胞自我更新中的作用[J]. 中国畜牧兽医, 2013, 40(10): 134-139 |
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| 作者姓名： | 劳艳萍 柯浩 孙洪亮 刘荣立 马玉洁 阮秋燕 雷钏 陆凤花 李湘萍 石德顺 |
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| 作者单位： | 亚热带农业生物资源保护与利用国家重点实验室, 广西南宁 530004 |
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| 基金项目： | 国家"863"项目(2011AA100607);国家自然科学基金项目(31072033)。 |
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| 摘 要： | 胚胎干细胞(embryonic stem cells,ES)是从早期囊胚内细胞团分离培养出来的能够不断维持自我更新和具有发育多能性的细胞。Wnt信号通路在维持胚胎干细胞的自我更新方面起着重要作用,糖原合成激酶 (glycogen synthase kinase-3,GSK-3)抑制剂可以激活Wnt信号通路,促进胚胎干细胞自我更新和增强细胞间连接。作者就GSK-3抑制剂在胚胎干细胞自我更新、细胞连接方面的作用及其作用机制进行简单综述。
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| 关 键 词： | 胚胎干细胞 Wnt 糖原合成激酶 6-bromoindirubin-3’-oxime CHIR99021 |
| 收稿时间： | 2013-03-12 |
Effect of Glycogen Synthase Kinase-3 Inhibitor on Maintaining Self-Renewal of Embryonic Stem Cells |
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| LAO Yan-ping,KE Hao,SUN Hong-liang,LIU Rong-li,MA Yu-jie,RUAN Qiu-yan,LEI Chuan,LU Feng-hua,LI Xiang-ping,SHI De-shun. Effect of Glycogen Synthase Kinase-3 Inhibitor on Maintaining Self-Renewal of Embryonic Stem Cells[J]. China Animal Husbandry & Veterinary Medicine, 2013, 40(10): 134-139 |
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| Authors: | LAO Yan-ping KE Hao SUN Hong-liang LIU Rong-li MA Yu-jie RUAN Qiu-yan LEI Chuan LU Feng-hua LI Xiang-ping SHI De-shun |
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| Affiliation: | Key Laboratory of Subtropical Bio-resource Conservation and Utilization in Guangxi Province, Nanning 530004, China |
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| Abstract: | Embryonic stem (ES) cells are derived from the inner cell mass of early blastocyst, and possess the ability of self-renewal and maintenance pluripotency. Wnt signaling pathway plays important roles in maintaining self-renewal of ES cells. Glycogen synthase kinase-3 (GSK-3) inhibitors can active Wnt signaling pathway,then promote the self-renewal and cell-to-cell adhesion of ES cells. In this paper, we take a review for the effect and mechanism of GSK-3 inhibitors on maintaining self-renewal and cell-to-cell adhesion of ES cells. |
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| Keywords: | embryonic stem cells Wnt glycogen synthase kinase-3 6-bromoindirubin-3’-oxime CHIR99021 |
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