分泌型IgA对肠道黏膜免疫的研究进展

分泌型IgA(secretory IgA,SIgA)作为一种包被于肠道黏膜的抗体,能保护肠道免受病原微生物和毒素的攻击而不引起炎症反应,对激活黏膜免疫和维持肠道内环境稳态起到重要作用。在动物肠腔中,SIgA能通过调节肠道上皮细胞受体的识别能力,阻断病原微生物侵入黏膜相关淋巴组织,随后在肠道蠕动和黏液绒毛的协助运动下,最终将病原微生物清除;且最近也有报道揭示SIgA在肠上皮胞吞转运作用下的新机制。因此,作者主要阐述SIgA在肠道黏膜免疫及其内环境方面发挥关键的生物学特征和功能,以及探讨胞吞转运机制下SIgA的潜在作用。

Research Advances on Secretory IgA Roles in Intestinal Mucosal Immunity

Secretory IgA (SIgA) as a antibody which is packaged in the intestinal mucosal, could protect the gut from pathogenic microorganisms and toxins attack without causing an inflammatory reaction, plays an important role in mucosal immunity and intestinal homeostasis. In animal intestine studies, SIgA blocks pathogenic microorganisms invade the mucosa-associated lymphoid tissue, through the regulation of intestinal epithelial cell receptor recognition ability. Subsequently SIgA promotes to entrap them in mucus, and facilitate their removal by peristaltic and mucociliary activities. In addition, recently it has also been reported that SIgA reveals new mechanism in intestinal epithelial cell. We summarize the intrinsic biological activities now associated with SIgA and their relationships with immunity and intestinal homeostasis,and try to explore the potential role of SIgA transcytosis mechanism.