| 双歧杆菌代谢母乳寡糖机制的研究进展 |
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| 引用本文： | 姜陈波,洪青,杭锋. 双歧杆菌代谢母乳寡糖机制的研究进展[J]. 乳业科学与技术, 2017, 40(6): 38-44. DOI: 10.15922/j.cnki.jdst.2017.06.008 |
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| 作者姓名： | 姜陈波 洪青 杭锋 |
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| 作者单位： | 光明乳业股份有限公司乳业研究院, 上海乳业生物工程技术研究中心, 乳业生物技术国家重点实验室, 上海 200436 |
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| 基金项目： | 上海市科学技术委员会工程中心能力提升项目(2016DZ2280600) |
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| 摘 要： | 母乳寡糖(human milk oligosaccharides,HMO)结构复杂,其能够选择性地促进母乳喂养婴儿肠道中益生菌双歧杆菌的生长。婴儿肠道相关双歧杆菌具有糖苷酶等分子工具,使其能够代谢HMO,且代谢过程具有菌株特异性。本文总结了HMO的结构特点,探讨了婴儿肠道相关双歧杆菌代谢HMO的机制,重点分析了双歧杆菌代谢HMO的种内差异以及代谢过程涉及到的分子工具的研究进展。
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| 关 键 词： | 双歧杆菌 母乳寡糖 代谢 糖苷水解酶, |
Advance in Understanding the Mechanism Underlying Bifidobacterial Metabolism of Human Milk Oligosaccharides |
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| JIANG Chenbo,HONG Qing,HANG Feng. Advance in Understanding the Mechanism Underlying Bifidobacterial Metabolism of Human Milk Oligosaccharides[J]. JOURNAL OF DAIRY SCIENCE AND TECHNOLOGY, 2017, 40(6): 38-44. DOI: 10.15922/j.cnki.jdst.2017.06.008 |
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| Authors: | JIANG Chenbo HONG Qing HANG Feng |
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| Affiliation: | (Shanghai Engineering Research Center of Dairy Biotechnology, State Key Laboratory of Dairy Biotechnology,Dairy Research Institute, Bright Dairy and Food Co. Ltd., Shanghai 200436, China) |
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| Abstract: | Human milk oligosaccharides (HMO) have complex structures and selectively stimulate the growth of probiotic bifidobacteria in the intestine of breast-fed infants. Infant gut-associated bifidobacteria provide molecular tools to metabolize HMO with strain specificity, such as glycosyl hydrolases. This review summarizes the structure of HMO and the mechanism underlying HMO metabolism by infant gut-associated bifidobacteria. The focus of this review is on the current advances in the intraspecific differences in bifidobacterial HMO metabolism and the tools involved in the metabolic process. |
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| Keywords: | bifidobacteria human milk oligosaccharides (HMO) metabolism glycosyl hydrolase, |
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