| 取代基对黄酮类化合物流感病毒神经氨酸酶抑制活性的影响 |
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| 引用本文： | 胡凤杨,陆春妮,汤有志.取代基对黄酮类化合物流感病毒神经氨酸酶抑制活性的影响[J].中国畜牧兽医,2012,39(2):144-147. |
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| 作者姓名： | 胡凤杨 陆春妮 汤有志 |
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| 作者单位： | 1. 华南农业大学兽医学院,广东广州 510642;2. 广东省兽药研制与安全评价重点实验室,广东广州 510642 |
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| 基金项目： | 国家自然科学基金，教育部博士点新教师基金，华南农业大学大学生科技创新活动项目 |
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| 摘 要： | 本试验旨在研究取代基对黄酮类化合物流感病毒神经氨酸酶(neuraminidase,NA)抑制活性的影响,为黄酮类流感病毒神经氨酸酶抑制剂的研发提供理论依据。应用流感病毒神经氨酸酶活性抑制试验评价了4种黄酮类化合物对NA的抑制活性。芹菜素-7-葡萄糖苷、芹菜素具有H9N2亚型流感病毒NA抑制活性,蒙花苷、汉黄芩苷无H9N2亚型流感病毒NA抑制活性。4'位的取代羟基对于黄酮类化合物的NA抑制活性不可或缺,7位的糖苷键能增强该类化合物的NA抑制活性。
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| 关 键 词： | 黄酮 芹菜素-7-葡萄糖苷 芹菜素 神经氨酸酶 抑制活性 |
| 收稿时间： | 2011-08-19 |
Influence of Substituent on the Neuraminidase Inhibitory Effect of Flavonoids |
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| HU Feng-yang
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LU Chun-ni
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TANG You-zhi.Influence of Substituent on the Neuraminidase Inhibitory Effect of Flavonoids[J].China Animal Husbandry & Veterinary Medicine,2012,39(2):144-147. |
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| Authors: | HU Feng-yang LU Chun-ni TANG You-zhi |
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| Institution: | 1. College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China;2. Guangdong Provincial Key Laboratory of Veterinary Drugs' Research and Safety Evaluation, Guangzhou 510642, China |
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| Abstract: | The substituent effects on neuraminidase(NA) inhibitory effect of flavonoids have been studied and could be used to provide experimental data for the exploitation of flavonoids as NA inhibitors.An assay method for evaluating the inhibitory activity of compounds on influenza viral NA was established and was used to evaluate the inhibitory effects of four flavone derivatives.Apigenin-7-glucoside and apigenin possessed inhibitory activity on H9N2 influenza viral NAs.Linarin and wogonoside did not possess inhibitory activity on H9N2 influenza viral NAs.The 4’-OH were essential for NA inhibitory effects of flavonoids and the 7-glycosidic bond could increase NA inhibition of flavonoids. |
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| Keywords: | flavonoids apigenin-7-glucoside apigenin neuraminidase inhibitory activity |
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