三种恩诺沙星注射液在猪体内的药物代谢动力学研究

三组猪分别按2.5 mg/kg的剂量肌肉注射拜有利5%、恩诺沙星注射液A、恩诺沙星注射液B三种药物,HPLC法测定血药浓度,Winnonlin6.1软件拟合血药浓度—时间数据,计算参数。三种注射液均符合一室开放模型,峰浓度分别为:0.87、0.63、0.49μg/mL,AUC分别为6.32、5.31、3.45 h.μg.mL-1。实验结果表明,拜有利5%在猪体内的药代动力学参数优于注射液B,注射液B的优于注射液A,提示恩诺沙星注射液B与拜有利5%相比临床防治效果略差,药物吸收可做进一步改进。

Pharmacokinetics of Three Enrofloxacin Injections in Swine

Three groups of swine（n=5） were injected intramuscularly Baytril 5%,enrofloxacin injection A,and enrofloxacin iniejction B.Plasma concentration was measured by HPLC,and concentration-time data was processed by Winnonlin6.1.The results showed that models of all groups were best fit by one-compartment open model with peak concentration of 0.87,0.63,0.49 μg/mL,and AUC of 6.32,5.31,3.45 h·μg·mL-1.Baytil 5% is the best in pharmacokinetics,then injection B,injection A last.It indicated that injection B was improved significantly,but slightly inferior to Baytril 5%.Its pharmacokinetic attribute of absorption should be improved.