Plasma cortisol concentrations following cortisone infusion in dogs before and after treatment with cortisone acetate |
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Authors: | Church D B Emslie D R Watson A D |
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Affiliation: | Department of Veterinary Clinical Sciences, University of Sydney, New South Wales. |
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Abstract: | OBJECTIVE: To evaluate effects of iatrogenic hyperadrenocorticism on plasma cortisol concentrations produced by an infusion of hydrocortisone in dogs. PROCEDURE: Plasma cortisol concentrations were measured regularly during a 6 h infusion of hydrocortisone sodium succinate at two dose rates. The infusions were performed before and after treatment for 30 d with oral cortisone acetate at 10 mg/kg/24 h, divided thrice daily. Adrenal activity during the experimental period was assessed by weekly ACTH stimulation tests. RESULTS: Both infusion rates produced lower plasma cortisol concentrations after treatment for 30 d with cortisone. CONCLUSION: Prior exposure to high concentrations of glucocorticoids may result in accelerated metabolism of glucocorticoids administered subsequently. This may necessitate increased dosages when using glucocorticoids to support inadequate adrenal function. |
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Keywords: | Dog cortisol cortisone glucocorticoid metabolism glucocorticoid therapy hydrocortisone infusion. |
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