Dynamic changes in inhibin messenger RNAs in rat ovarian follicles during the reproductive cycle |
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Authors: | T K Woodruff J D'Agostino N B Schwartz K E Mayo |
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Institution: | Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208. |
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Abstract: | The alterations in morphology and function of the ovarian follicle as it matures, ovulates, and becomes a corpus luteum are dramatic. A variety of steroid and polypeptide hormones influence these processes, and the ovary in turn produces specific hormonal signals for endocrine regulation. One such signal is inhibin, a heterodimeric protein that suppresses the secretion of follicle-stimulating hormone from pituitary gonadotrophs. Rat inhibin complementary DNA probes have been used to examine the levels and distribution of inhibin alpha-and beta A-subunit messenger RNAs in the ovaries of cycling animals. Striking, dynamic changes have been found in inhibin messenger RNA accumulation during the developmental maturation of the ovarian follicle. |
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