益生菌发酵驼乳对慢性肾功能衰竭的治疗作用

目的：比较不同菌种发酵的驼乳制品对腺嘌呤所致大鼠慢性。肾功能衰竭（CRF）的缓解作用。方法：采用腺嘌呤复制CRF大鼠模型，以不同发酵剂发酵的驼乳作为受试物进行灌胃干预。通过检测大鼠的饮食饮水情况、排尿量、尿液和血清常规指标及肾脏病理组织学变化，评估各发酵驼乳对CRF大鼠的治疗效果。结果：发酵驼乳均可改善肾功能衰竭大鼠的一般生理状况，可降低大鼠血肌酐（Scr）、尿素氦（BUN）水平，减缓尿蛋白（UP），调节Ca、P的含量，提高过氧化物歧化酶（SOD）、血清总蛋白（STP）水平，具有保护肾功能的作用，其中LIcaseiZhang发酵的驼乳对CRF大鼠的改善效果最佳。

The rapeutic Action of Probiotic Fermented Camel Milk on Chronic Renal Failure Rats Caused by Adenine

Purpose： To compare the different therapeutic Failure（CRF） of rats. Method： CRF rat models induced by fermentation camel milk. And then evaluated the therapeutic action of probiotics felTnented camel milk on Chronic Renal adenine were received intragastric administration with probiotic effect of three kinds of fermented camel milk by measure the diet and water intake, weight, kidney index, serum creatinine（Scr）, Urea Nitrogen（BUN）, nitric oxide（NO）, superoxide dismutase（SOD）, serum total protein（STP）, calcium（Ca）, phosphorus（P）, urine volume in 24 hours, urine protein（UP） and the Renal Biopsy. Result： The result showed that fermentation camel milk can reduce the serum level of Set and BUN, slow down UP, ameliorate the balance of calcium and phosphorus, enhanced the level of SOD and STP and alleviated pathological changes of the kidney tissue. Conclusion： Different kinds of probiotic fermented camel milk are effective in treating CRF of rats and the effect of camel milk fermented by L.casei Zhang is superior to camel milk fermented by other probiotics.