氟苯尼考PEG6000固体分散体在大鼠体内的生物利用度研究 |
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引用本文: | 于欣洋,赵修华,祖元刚,刘洋. 氟苯尼考PEG6000固体分散体在大鼠体内的生物利用度研究[J]. 安徽农业科学, 2014, 0(9): 2613-2614,2616 |
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作者姓名: | 于欣洋 赵修华 祖元刚 刘洋 |
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作者单位: | 东北林业大学森林植物生态学教育部重点实验室; |
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基金项目: | 国家科技支撑计划课题(2012BAD21B05) |
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摘 要: | [目的]研究氟苯尼考PEG6000固体分散体在大鼠体内的生物利用度.[方法]建立大鼠血浆中氟苯尼考的HPLC检测方法.用灌喂药物水溶液的方法,通过高效液相分析技术对氟苯尼考PEG6000固体分散体的血药浓度进行测定,与氟苯尼考原粉进行对照.[结果]氟苯尼考PEG6000固体分散体在大鼠体内吸收及代谢良好,氟苯尼考固体分散体和氟苯尼考原药的最高血药浓度分别为13.44和3.88 μ.g/ml,提高了3.46倍;药-时曲线下面积分别为:氟苯尼考原粉AUC0-8h=20.12 25 μg/(ml·h)、氟苯尼考固体分散体AUC0-8h=23.22μg/(ml·h),氟苯尼考-PEG6000固体分散体口服生物利用度与氟苯尼考原粉相比提高了15.39%.[结论]氟苯尼考-PEG6000固体分散体能显著提高氟苯尼考的生物利用度.
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关 键 词: | 氟苯尼考PEG6000固体分散体 生物利用度 高效液相分析技术 |
Bioavailability Study of Florfenicol-Polyethyleneglycol 6000 Solid Dispersion in Rats |
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Affiliation: | YU Xin-yang-, ZU Yuan-gang et al (Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, Heilongjiang 150040) |
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Abstract: | [ Objective] To study the bioavailability of florfenicol-polyethyleneglycol 6000 solid dispersion in rats. [ Method ] Set up a HPLC method for florfenicol in rat plasma. The plasma concentration of florfenicol- polyethyleneglycol 6000 solid dispersion is tested by HPLC analysis after being fed with drug solution, and is compared with that of raw florfenicol. [ Result] The absorption and metabolism of florfenicol- polyethyleneglycol 6000 solid dispersion are good in rats. The maximum plasma concentration of florfenicolpolyethyleneglycol 6000 solid dispersion and raw florfenicol are 13.44 and 3.88 μg/ml, respectively. The former is increased by 3.46 times ; The condition of AUC : raw florfenicol : AUC0-8 h = 20. 122 5 μg/( ml . h) ; florfenicol- polyethyleneglycol-6000 solid dispersion: AUC0-8h = 23.22 μg/( ml . h). Compared with raw florfenicol ,the oral bioavailability of florfenicol-polyethyleneglycol-6000 solid dispersion increased by 15.39%. [ Conclusion] Florfenicol-polyethyleneglycol-6000 solid dispersion can significantly increase the bioavailability of florfenicol. |
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Keywords: | Florfenicol- polyethyleneglycol 6000 solid dispersion Bioavailability HPLC analysis |
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