头孢喹肟研究进展

头孢喹肟(cefquinome)是第4代头孢菌素类动物专用抗生素,是一种治疗动物严重感染的新药,具有独特的抗菌机制和良好的抗菌活性,其抗菌谱广、抗菌活性强,药动学优良,血药浓度达峰时间短、浓度高,无致癌性、致突变性、致畸性、无繁殖毒性。对其作用机理、理化性质、药理学性质及合成路线等方面进行综述,并分析头孢喹肟在合成中存在收率低、处理困难等问题,以便医药科技工作者全面了解,进而用以指导临床应用。

Research Advance on Cefquinome

As the fourth generation of aminothiazolyl cephalosporin,cefquinome was developed especially for using in animals, and a new drug for animal severe infection, which had antibacterial mechanism and antibacterial activity. Cefquinome was known as broad antibacterial spectrum, strong antibacterial activity, superior pharmacokinetics, and no carcinogenicity, mutagenicity, teratogenicity, reproductive toxicity. The blood concentration of cefquinome reached its peak in short time, and had high concentration. The paper summarized the cefquinome’s antibacterial activity, physicochemical properties and pharmacological properties, synthetic routes, a number of problems in synthesizing cefquinome, such as low yield and post treatment difficult were also analyzed, to lead pharmaceutical scientific worker with thorough knowledge and guide clinical application.