| 高血压病患者血浆白细胞介素18水平的检测与分析 |
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| 引用本文： | 许金成,王淑斐,刘华锋,袁岩,洪玉芬. 高血压病患者血浆白细胞介素18水平的检测与分析[J]. 湛江医学院学报, 2004, 22(4): 331-332 |
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| 作者姓名： | 许金成 王淑斐 刘华锋 袁岩 洪玉芬 |
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| 作者单位： | 广东省深圳市宝安人民医院心内科,广东宝安,518101;广东医学院肾脏病研究所,广东湛江,524023;广东医学院附属医院心内科,广东湛江,524001 |
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| 基金项目： | 广东省卫生厅科研基金立项课题 (A2 0 0 1 4 88) |
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| 摘 要： | 目的 :了解白细胞介素 1 8(IL- 1 8)在高血压病发病机制中的作用。方法 :采用双抗体夹心法 ELISA法对不同等级的高血压病患者和高血压病合并心力衰竭患者 35例及 30名健康者的血浆 IL- 1 8水平作了检测和比较。结果 :高血压病患者血浆 IL- 1 8水平显著高于正常对照组 (t=4.60 3,P<0 .0 0 1 ) ,并随高血压病级别的上升而升高 (P均 <0 .0 5) ;合并心力衰竭患者血浆 IL- 1 8水平显著高于无心力衰竭者 (t=2 .81 ,P<0 .0 1 )。结论 :高血压病的发生可能有 IL- 1 8参与。
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| 关 键 词： | 高血压病 白细胞介素18 心力衰竭 |
| 文章编号： | 1005-4057(2004)04-0331-02 |
| 修稿时间： | 2004-02-16 |
Plasma levels of interleukin 18 in patients with primary hypertension |
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| XU Jin-cheng ,WANG Shu-fei ,LIU Hua-feng ,YUAN Yan ,HONG Yu-feng. Plasma levels of interleukin 18 in patients with primary hypertension[J]. Journal of Guangdong Medical College, 2004, 22(4): 331-332 |
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| Authors: | XU Jin-cheng WANG Shu-fei LIU Hua-feng YUAN Yan HONG Yu-feng |
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| Affiliation: | XU Jin-cheng 1,WANG Shu-fei 1,LIU Hua-feng 2,YUAN Yan 3,HONG Yu-feng 3 |
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| Abstract: | Objective:To investigate the role of interleukin 18 (IL-18) in the pathogenesis of primary hypertension (PH). Methods:Plasma levels of IL-18 in 35 patients with PH and 30 health controls were measured by ELISA. Result:IL-18 contents in patients with PH were significantly higher than those in normal controls (t=4.603,P<0.001), which varied with the degree of PH (P<0.05). Furthermore, IL-18 concentrations were remarkably increased in patients with heart failure (HF) as compared with those without HF (t=2.81, P<0.01). Conclusion:IL-18 could be involved in the pathogenesis of PH. |
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| Keywords: | hypertension interleukin 18 heart failure |
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