| nm23基因的表达与皮肤鳞癌发生、发展及转移的关系 |
| |
| 引用本文： | 李慧忠,李顺凡,吴国凤,樊翌明,吴志华.nm23基因的表达与皮肤鳞癌发生、发展及转移的关系[J].湛江医学院学报,2003,21(5):440-441,444. |
| |
| 作者姓名： | 李慧忠 李顺凡 吴国凤 樊翌明 吴志华 |
| |
| 作者单位： | [1]广东省清远市人民医院皮肤科，广东清远511500 [2]广东医学院附属医院皮肤科，广东湛江524001 |
| |
| 摘 要： | 目的：观察nm23表达与皮肤鳞状细胞癌(鳞癌)发生、发展与转移的关系。方法；采用免疫组织化学及图像分析技术检测66例皮肤鳞癌、12例淋巴结转移灶、21例假上皮瘤样增生及20例正常皮肤中nm23表达情况。结果：皮肤鳞癌中nm23表达下调，但鳞癌中nm23表达与鳞癌的转移、TNM分期、病理分化程度及发病部位无关。结论：nm23基因表达下调是发生在鳞癌演进过程中的一个早期事件。nm23可能不具有抑制皮肤鳞癌转移的功能。
|
| 关 键 词： | 癌 鳞状细胞 nm23 免疫组织化学 图像分析 |
| 文章编号： | 1005-4057(2003)05-0440-03 |
Relationship between nm23 expression and development,progression and metastasis of cutaneous squamous cell carcinoma |
| |
| LI Hui zhong ,LI Shun fan ,WU Guo feng ,et al.Relationship between nm23 expression and development,progression and metastasis of cutaneous squamous cell carcinoma[J].Journal of Guangdong Medical College,2003,21(5):440-441,444. |
| |
| Authors: | LI Hui zhong LI Shun fan WU Guo feng |
| |
| Institution: | LI Hui zhong 1,LI Shun fan 2,WU Guo feng 2,et al |
| |
| Abstract: | Objective:To investigate the relationship of nm23 expression and development,progression and metastasis of cutaneous squamous cell carcinoma (SCC).Methods:Morphometric technique was used to assess immunostaining of nm23 from 20 normal skin samples,21 pseudoepitheliomatous hyperplasias,66 SCCs and 12 lymph node metastases.Results:Expression of nm23 was down regulated in SCC and not correlated with metastasis,TNM stages,pathologic grades and location.Conclusion:The down regulation of nm23 expression may be the early event in the development of SCC.nm23 could not be a metastatic suppressor in cutaneous SCC. |
| |
| Keywords: | squamous cell carcinoma nm23 immunohistochemistry morphometry |
| 本文献已被 CNKI 维普 等数据库收录！ |
