液基薄层细胞学检测技术在肺癌诊断中的作用

目的 探讨液基薄层细胞学检测(TCT)技术在肺癌诊断中的应用价值。方法 收集400例肺癌患者和200例非肺癌患者的痰液、胸腔积液、支气管肺泡灌洗液及支气管刷片共600例,同时进行TCT和传统涂片法(CS)检测,比较两种方法的敏感度和特异度。结果 TCT检测的敏感度为73.0%,特异度为97.5%,CS法检测的敏感度为29.0%,特异度为99.5%,TCT检测的敏感度高于CS法(P<0.05)。TCT法在涂片质量、判断癌细胞形态学方面均较CS法好。TCT分类诊断和病理组织学诊断的总符合率为86.6％。TCT分类诊断和细胞蜡块结合免疫细胞化学诊断的总符合率为89.0％。结论 TCT检测法能明显提高肺癌细胞的阳性检出率,值得推广应用。

Application of ThinPrep cytology test in the diagnosis of lung cancer

Objective To explore the diagnostic value of ThinPrep cytology test (TCT) in lung cancer. Methods Six hundred samples of sputum,pleural effusion,alveolar lavage fluid and bronchial mucosa brush were collected,including 400 cases of lung cancer patients and 200 cases of benign lung disease patients.They were detected by TCT and method of conventional smear (CS),respectively.The sensitivity and specificity of the two methods were compared. Results The sensitivity of TCT was higher than that of CS (73.0% vs 29.0%,P<0.05) and the specificities of TCT and CT were 97.5% and 99.5%,respectively.TCT is better than CS in the smear quality and the morphology of cancer cell.TCT concordance rates with histopathological diagnosis and diagnosis of cell block in combination with immunocytochemistry were 86.6% and 89.0%,respectively. Conclusions TCT can increase the detection rate of lung cancer and is worthy of application in clinical practice.