| 余甘子对强致癌物N-亚硝基化合物在人体内合成的阻断作用 |
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| 引用本文： | 侯开卫,刘凤书,杨臣武,宋圃菊,梁学军,程列.余甘子对强致癌物N-亚硝基化合物在人体内合成的阻断作用[J].林业科学研究,1989,2(1):55-58. |
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| 作者姓名： | 侯开卫 刘凤书 杨臣武 宋圃菊 梁学军 程列 |
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| 作者单位： | 中国林业科学研究院资源昆虫研究所
(侯开卫，刘凤书，杨臣武)，北京医科大学
(宋圃菊，梁学军)，北京医科大学(程列) |
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| 摘 要： | 本文采用Ohshima的方法,以尿中N-亚硝基脯氨酸(NPRO)量为指标,研究了余甘子果汁阻断人体内N-亚硝基化合物(NNC)的合成。12名志愿者摄入L-脯氨酸500 mg和硝酸钠300 mg后,尿中NPRO的量平均为75.10 nmol,而当摄入上述两种药物的同时,分别给予同浓度的抗坏血酸和余甘子果汁后,尿中NPRO的含量则分别降为41.08 nmol和20.79nmol,且后者此本底值(25.55 nmol)还低。表明在本实验条件下,摄入含抗坏血酸75mg的余甘子果汁13ml,即能完全阻断500mg L-脯氨酸和300mg硝酸钠在人体内所引起的NPRO的合成。同时也证明,余甘子果汁能有效地阻断人体内NNC的合成。
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| 关 键 词： | 余甘子 N-亚硝基化合物 N-亚硝基脯氨酸 L-脯氨酸 硝酸钠 抗坏血酸 |
THE BLOCKING EFFECT OF PHYLLANTHUS EMBLICA L. ON THE FORMATION OF STRONG CARCINOGEN N-NITROSO COMPOUND IN HUMAN BODY |
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| Hou Kaiwei Liu Fengshu Yang ChenwuThe Research Institute of Economic Insects CAF Song Puju Liang Xuejun Cheng LieBeijing Medical University.THE BLOCKING EFFECT OF PHYLLANTHUS EMBLICA L. ON THE FORMATION OF STRONG CARCINOGEN N-NITROSO COMPOUND IN HUMAN BODY[J].Forest Research,1989,2(1):55-58. |
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| Authors: | Hou Kaiwei Liu Fengshu Yang ChenwuThe Research Institute of Economic Insects CAF Song Puju Liang Xuejun Cheng LieBeijing Medical University |
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| Institution: | Hou Kaiwei Liu Fengshu Yang ChenwuThe Research Institute of Economic Insects CAF Song Puju Liang Xuejun Cheng LieBeijing Medical University |
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| Abstract: | The paper deals with the blocking effect of Phyllanthus emblica L. on the formation of N-nitroso-compound in human body. Ohshima's method was used to measure the quantity of N-nitroso-proline (NPRO) in urine as an index. Each one of the twelve tested men absorbed 500 mg L-proline and 300 mg sodium nitrate, after that, the average quantity of N-nitroso-proline in their urine was 75.10nmol. However, when absorbing L-proline and sodium nitrate, they absorbed again ascorbic acid and Phyllanthus emblica L. juice of the same concentration with ascorbic acid separately. The content of NPRO in their urine was down to 41.08nmol and 20.79nmol respectively. The content of NPRO of the latter is lower than background number (25.55 nmol). It indicated that if a man absorbed 13ml Phyllanthus emblica L. juice containing 75 mg ascorbic acid in this experiment, the synthesis of NPRO, which was formed by absorbing 500 mg L-proline and 300 mg sodium nitrate in human body could be blocked. Besides, it also showed that the Phyllanthus emblica juice could block the synthesis of N-nitroso-compound in human body effectively. |
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| Keywords: | Phyllanthus cmblica L N-nitroso-compound N-nitroso-proline L-proline sodium nitrate ascorbic acid |
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