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| 细菌菌蜕的研究进展 | |
| 引用本文： | 罗满林. 细菌菌蜕的研究进展[J]. 中国兽药杂志, 2010, 44(11): 50-54 |
| 作者姓名： | 罗满林 |
| 作者单位： | 1. 广东大华农动物保健品股份有限公司,广东云浮,527400;华南农业大学兽医学院,广州,510642 2. 华南农业大学兽医学院,广州,510642 3. 广东大华农动物保健品股份有限公司,广东云浮,527400 |
| 摘 要： | 菌蜕是通过基因灭活的方法,利用噬菌体PhiX174的裂解蛋白E在革兰氏阴性菌细胞膜上形成一个跨膜孔道结构使其胞质内容物由孔道排出所形成的细菌空壳结构。这种空壳结构因其保留了细菌的完整结构,不仅可用作疫苗制备的抗原物质,还可作为药物、异源抗原、核酸等的递送载体,具有广泛的应用前景。 |
| 关 键 词： | 细菌 菌蜕 疫苗 递送载体 |
| 收稿时间： | 2009-09-15 |
| 修稿时间： | 2010-03-04 |
Research Progress on Bacterial Ghosts |
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| Luo Manlin. Research Progress on Bacterial Ghosts[J]. Chinese Journal of Veterinary Drug, 2010, 44(11): 50-54 | |
| Authors: | Luo Manlin |
| Affiliation: | 1.Dahuanong Animal Health Products Co.,Ltd,Yunfu,Guangdong 527400,China;2.College of Veterinary medicine,South China Agriculture University,Guangzhou 510642,China) |
| Abstract: | Bacterial ghosts are nondenaturated empty cell envelopes of gram-negative bacteria produced by E-mediated lysis.Within E-cracking protein of bacteriophage PhiX174,a pore canal will formed on the gram-negative bacteria＇s cell membrane,and the cell-inner will exhause,which is called gene inactivation.The nondenaturated empty cell envelopes can be antigens of vaccines,and delivery carriers of medcines,alloantigens,and nucleic acids because of intact bacterial structure.So bacterial ghosts have widely applicable prospect. |
| Keywords: | bacterial ghosts vaccine delivery carrier |
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