Multihydroxylation of ursolic acid by Pestalotiopsis microspora isolated from the medicinal plant Huperzia serrata |
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| Authors: | Shao-bin Fu Jun-shan Yang Jin-long Cui Qing-feng Meng Xu Feng Di-An Sun |
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| Institution: | aInstitute of Medical Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China;bNo 1 senior middle school of laiwu, Shandong, 271100, China;cNavy Medical Research Institute, Shanghai 200433, China |
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| Abstract: | The structural modification of ursolic acid by an endophytic fungus Pestalotiopsis microspora, isolated from medicinal plant Huperzia serrata was reported for the first time. The structure diversity was very important for the SAR study of ursolic acid and its derivatives. Incubation of ursolic acid 1 with P. microspora afforded four metabolites: 3-oxo-15α, 30-dihydroxy-urs-12-en-28-oic acid (2), 3β, 15α-dihydroxy-urs-12-en-28-oic acid (3), 3β, 15α, 30- trihydroxy-urs-12-en-28-oic acid (4) and 3,4-seco-ursan-4,30-dihydroxy-12-en-3,28-dioic acid (5). All products were new compounds and their structures elucidation was mainly based on the spectroscopic data. |
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| Keywords: | Biotransformation Ursolic acid Endophytic fungus Huperzia serrata Pestalotiopsis microspora |
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