Bioactive saponins from the fruits of Aesculus pavia L |
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Authors: | Sun Zhen-Liang Zhang Ming Wu Ying Wan Ai-Hong Zhang Rong |
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Institution: | aBranch hospital in Fengxian of Shanghai No. 6 people's hospital, 9588 Nanfeng Road, Shanghai 201400,PR China |
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Abstract: | Continued chemical investigation on the fruits of Aesculus pavia L. resulted in theisolation and identification of two new oleanolic acid saponins, namely vaccaroside A (1) andvaccaroside B (2). The isolated furostanol saponins were evaluated for cytotoxic activity againsthuman normal amniotic and human lung carcinoma cell lines using neutral red and MTT assays.In vitro experiments showed significant cytotoxicity in a dose dependent manner with IC50 valuesin the range of 27.80–79.02 μM. |
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Keywords: | Aesculus pavia L Vaccaroside A Cytotoxic activity |
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