Cytotoxic alkaloids from stems, leaves and twigs of Dasymaschalon blumei |
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| Authors: | Chanakul Waraporn Tuchinda Patoomratana Anantachoke Natthinee Pohmakotr Manat Piyachaturawat Pawinee Jariyawat Surawat Suksen Kanoknetr Jaipetch Tharworn Nuntasaen Narong Reutrakul Vichai |
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| Institution: | aDepartment of Chemistry and the Center for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama VI Road, Bangkok, 10400, Thailand;bDepartment of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Sri-Ayuthaya Road, Bangkok, 10400, Thailand;cDepartment of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Rajthevi, Bangkok, 10400, Thailand;dMahidol University, Kanchanaburi Campus, Saiyok, Kanchanaburi 71150, Thailand;eThe Forest Herbarium National Park, Wildlife and Plant Conservation Department, Ministry of Natural Resources and Environment, Bangkok, Thailand |
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| Abstract: | Bioassay-guided fractionation of the cytotoxic ethyl acetate extract from the stems of Dasymaschalon blumei (Annonaceae) led to the isolation of four aristololactam alkaloids, including the hitherto unknown 3,5-dihydroxy-2,4-dimethoxyaristolactam (1), as well as the three known compounds, aristolactam BI, goniopedaline, and griffithinam. Additionally, the cytotoxic extract from the combined leaves and twigs of the same plant yielded three known oxoaporphine alkaloids, oxodiscoguattine, dicentrinone, and duguevalline. The structures of aristolactams and oxoaporphine alkaloids were elucidated on the basis of spectroscopic methods. All isolates were evaluated for cytotoxicity against a panel of mammalian cancer cell lines and a noncancerous human embryonic kidney cell Hek 293. |
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| Keywords: | Dasymaschalon blumei Cytotoxicity Alkaloid Aristolactam Oxoaporphine |
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