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Evidence that active transmission of porcine cysticercosis occurs in Venezuela |
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| Authors: | Cortez Alcobedes Maria M Boggio Gonzalo Guerra Ma de Lourdes de Gavidia Magda Rodríguez Rojas Reyes Glenda C Ferrer Elizabeth Lares Maria Alviarez Yenny Harrison Leslie J S Parkhouse R Michael E |
| Institution: | 1.Instituto de Investigaciones Biomédicas (BIOMED) Facultad de Ciencias de la Salud, Sede Aragua, Universidad de Carabobo, Final C/Cecilio Acosta, Av. Las Delicias, Urb. La Rinconada, Maracay, Estado Aragua, P. O. Box 2351, Maracay, Venezuela ;2.Coordinación de Extensión, Facultad de Agronomía, Universidad Central de Venezuela, Maracay, Venezuela ;3.Cátedra de Epidemiología, Facultad de Ciencias Veterinarias, Universidad Central de Venezuela, Maracay, Venezuela ;4.Dirección de Salud Ambiental, Ministerio de Salud, Av. Las Delicias, frente al Círculo Militar, Maracay, Estado Aragua, Venezuela ;5.Departamento Clínico Integral, Escuela de Bioanálisis, Facultad de Ciencias de la Salud, Sede Aragua, Universidad de Carabobo, Maracay, Venezuela ;6.Departamento de Parasitología, Escuela de Medicina, Facultad de Ciencias de la Salud, Sede Aragua, Universidad de Carabobo, Maracay, Venezuela ;7.Royal (Dick) School of Veterinary Studies, Easter Bush Veterinary Centre, The University of Edinburgh, Easter Bush, Roslin, Midlothian, Scotland, UK, EH259RG ;8.Instituto Gulbenkian de Ciéncia, Rua Quinta Grande 6, 2780-156, Oeiras, Portugal ; |
| Abstract: | There is a paucity of quantitative data on the status of porcine cysticercosis in Venezuela, information which is essential for understanding the level of disease transmission. This study was, therefore, conducted in a typical small rural community in Yaracuy State, Venezuela, where previous cases of human Taenia solium taeniasis/cysticercosis had been reported and where the free-ranging pig management practices and the lack of rudimentary sanitary facilities indicated an obvious risk for transmission of the disease. Serum samples from 52 village pigs were screened by enzyme-linked immunosorbent assays for anti-cysticercal antibodies (Ab-ELISA), using T. solium cyst fluid as the antigen and the HP10, monoclonal antibody-based, antigen trapping ELISA for parasite antigen (HP10 Ag-ELISA). Significantly, a high proportion of the animals (65.4% for the Ab-ELISA and 42.3% for the HP10 Ag-ELISA) were sero-positive. Five of the pigs, which were selected on that basis of positive tongue palpation, were killed for autopsy, and large numbers of viable cysticerci were found in the carcases. This unequivocal documentation of porcine cysticercosis in Venezuelan pigs presents clear evidence that T. solium is actively transmitted in Venezuela. Further detailed studies and implementation of appropriate control measures are therefore indicated. |
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