The mobilization of copper in sheep by chelating agents. |
| |
| Authors: | Nils E Sli Arne Frslie Jan Aaseth |
| |
| Institution: | 110.Department of Pharmacology and Toxicology, Veterinary College of Norway, P. O. Box 8146, Oslo Dep., Oslo 1, Norway ;210.National Veterinary Institute, Oslo and the Institute of Occupational Health, Oslo, Norway |
| |
| Abstract: | D-penicillamine and 2,3-dimercapto-propane-l-sulphonate (DMPS) were administered orally and disodium-calcium-ethylene-diamine-tetraacetate (Ca-EDTA) subcutaneously into copper loaded sheep. The results showed that D-penicillamine has a copper mobilizing effect, while DMPS and Ca-EDTA do not seem to have this effect to any significant degree. Penicillamine, 52 mg/kg of body weight daily for 6 days, increased the urinary excretion of copper by a factor of 10 to 20. The same dosage (on weight basis) of DMPS increased the excretion of copper in urine by 2 fold. Following Ca-EDTA treatment no increase in urinary excretion of copper was observed. Penicillamine could be used in prophylactic treatment of copper toxicosis in sheep, but it is still too expensive for practical use. |
| |
| Keywords: | copper chelating agents excretion sheep |
|
|
