线粒体与细胞凋亡的关系

线粒体是细胞能量合成和贮存及物质代谢、能量转化的重要场所，不仅能诱导细胞凋亡，还是细胞凋亡的执行者。在细胞凋亡过程中，与凋亡相关的活性物质，如细胞色素C（Cyt·c）、凋亡诱导因子（AIF）、B细胞淋巴瘤基因-2（Bcl-2）等从线粒体释放到膜间隙中，使线粒体膜通透性转换孔（mitochondrion permeability transition pore，MPTP）开放，削弱线粒体膜两侧的质子梯度，导致线粒体膜电位降低，诱导细胞凋亡。同时线粒体内的Bcl-2家族对细胞凋亡具有调节作用。笔者就MPTP、Cyt·c、AIF、Bcl-2与细胞凋亡的关系进行了综述。

The Relationship between Mitochondria and Apoptosis

itochondria is an important site for cellular energy production and storage， material metabolism, energy transformation.It not only induce apoptosis,but also be the executor of apoptosis.In the process of apoptosis,the active substances of apoptosis-related such as cytochrome C(Cyt·c),apoptosis inducing factor(AIF),B cell lymphoma gene-2(Bcl-2)release from mitochondria to the gap of the membrane that made the mitochondrial permeability transition pore(MPTP) opening,reduced mitochondrial membrane proton gradient on both side,lead to mitochondrial membrane potential cut down, induced apoptosis at last.At the same time,the Bcl-2 family can regulate apoptosis.In this paper,the relationship of MPTP, Cyt·c, AIF, Bcl-2 and apoptosis are reviewed.