| 苦马豆素人工抗原对家兔的免疫原性研究 |
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| 引用本文： | 王帅,陈根元,胡建军,张玲,马春晖.苦马豆素人工抗原对家兔的免疫原性研究[J].中国草食动物,2012(2):64-66. |
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| 作者姓名： | 王帅 陈根元 胡建军 张玲 马春晖 |
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| 作者单位： | 新疆生产建设兵团塔里木畜牧科技重点实验室塔里木大学动物科学学院 |
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| 基金项目： | 新疆生产建设兵团博士资金专项(2008JC07) |
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| 摘 要： | 试验分析了苦马豆素人工抗原SW-BSA对家兔的免疫原性,通过免疫学指标的评价,为免疫学检测和防治动物疯草中毒奠定基础。将18只家兔随机分为对照组(6只)、免疫Ⅰ组(6只)、免疫Ⅱ组(6只),免疫组依次进行首免和加强免疫,然后通过IHA和ELISA法分析血清抗体的变化规律,同时检测试验家兔E-玫瑰花环率的变化。结果显示,SW-BSA可以诱导机体产生高效价的抗SW抗体,而且高效价保持时间较长,机体E-玫瑰花环率也有所上升。表明合成的SW-BSA具有较好的免疫原性。
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| 关 键 词： | 苦马豆素 人工抗原 家兔 免疫 |
Study on Immunogenicity of Artificial Antigen of Swainsonine in Rabbits |
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| Wang Shuai,Chen Gen-yuan,Ma Chun-hui.Study on Immunogenicity of Artificial Antigen of Swainsonine in Rabbits[J].China Herbivores,2012(2):64-66. |
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| Authors: | Wang Shuai Chen Gen-yuan Ma Chun-hui |
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| Institution: | ,et al(Key Laboratory of Tarim Animal Husbandry Science and Technology,Xinjiang Production & Construction Corps College of Animal Science,Tarim University,Alar 843300,China) |
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| Abstract: | By analyzing the influence of artificial antigen of swainsonine(SW-BSA) in immunized rabbits with immunology index for accumulating knowledge for prophylaxis and healing of intoxication which produced by locoweed,18 rabbits were divided into control group(6 rabbits),immunity Ⅰ group(6 rabbits),immunity Ⅱ group(6 rabbits) randomly,two immunity groups were carried on initial immunization and booster immunization.Then the change regularity of antibody in serum by indirect hem agglutination and enzyme linked immunosorbent assay,and change of E-rosette rate was detected.The results showed that high titer of antibody against swainsonine was produced by SW-BSA and could retain long time,E-rosette rate increased also.It was concluded that artificial antigens of SW-BSA had better immunogenicity to rabbit. |
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| Keywords: | swainsonine artificial antigen rabbit immuniz-ation |
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