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Workshop studies with monoclonal antibodies identifying a novel porcine differentiation antigen, SWC9 |
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| Authors: | J Dominguez A Ezquerra F Alonso R Bullido K McCullough A Summerfield A Bianchi R J Zwart Y B Kim F Blecha S Eicher M P Murtaugh M Pampusch K Burger |
| Institution: | a Centro de Investigación en Sanidad Animal INIA, Valdeolmos, 28130 Madrid, Spain b Institute of Virology and Immunoprophylaxis, CH-3147 Mittelhäusern, Switzerland c Central Veterinary Institute ID-DLO, PO BOX 65, 8200 AB Lelystad, Netherlands d Department of Microbiology and Immunology, Finch University of Health Sciences, The Chicago Medical School, North Chicago, IL 60064, USA e Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, USA f Department of Veterinary Pathobiology, University of Minnesota, St. Paul, MN 55108, USA |
| Abstract: | Two monoclonal antibodies (mAb) within cluster M4 of the myeloid section of the Second International Swine CD Workshop, C4 (No. 144) and PM18-7 (No. 192), showed reactivity with thymocytes and among cells of myelomonocytic origin with mature macrophages but not with monocytes and granulocytes. Both mAb recognize a protein showing two bands of 205 kDa and 130 kDa under both reducing and non-reducing conditions. Although epitope mapping with these mAb could not be performed, this cluster received the SWC9 designation. |
| Keywords: | Monoclonal antibody Macrophage Differentiation antigen |
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