国内外穿心莲研究态势分析

为了解穿心莲(Andrographis paniculata)的研究现状和学科发展,通过科学网(Web of Science,WoS)核心合集搜索2001—2020年发表的穿心莲SCI学术论文,结合文献计量学描述性和关联性指标,明确穿心莲近20年的科研态势。结果表明：（1）2019—2020年穿心莲的年发文量突破100篇,多数以穿心莲内酯的抑癌功能为核心展开。（2）虽然发文量最多的国家是印度、中国和马来西亚,但中国与美国和澳大利亚的合著关系最近。结合发文量、H指数与论文年均被引数,美国仅凭中国发文量1/5的产出就达到与中国持平的国际影响力,成果受到高度重视,中国穿心莲论文质量仍需提高。（3）印度科学工业研究理事会(CSIR)和新加坡国立大学是被引频次最高的穿心莲科研机构。台湾中华医科大学、中国科学院、上海中医药大学和中山医学大学是中国主要的穿心莲科研机构。（4）穿心莲发文量前3名作者均来自中国。（5）新加坡国立大学Wong W S F团队于2009年发表穿心莲至今为止影响因子最高(21.4)的学术论文,阐明穿心莲内酯缓解哮喘的分子机制。“天然抗生素”穿心莲内酯抑制新型冠状病毒蛋白活性的功能公开引起国际学者的高度重视,关于穿心莲药理药效和高产稳产等基础研究将更加深入。

Advances in Scientific Research on Andrographis paniculata

This study aims to understand the research status and disciplinary development of Andrographis paniculata (AP). By searching the core collection of Web of Science (WoS) SCI academic papers published from 2001 to 2020, and combining with bibliometrics descriptive and correlation indicators, the research situation of AP in the 20 years was clarified. The results are as follows. (1) In 2019-2020, the annual number of papers published on AP exceeded 100, most of which focused on the anti-cancer function of andrographolide. (2) Although India, China and Malaysia were the countries with the largest number of publications, China had the most recent coauthored relationships with the United States and Australia. Considering the number of papers published, H index and annual citations of papers, the United States achieved international influence equal to that of China with only 1/5 of the published papers of China. The research results of the United States were highly valued, and the quality of Chinese papers still needs to be improved. (3) The most frequently cited research institutions of AP were CSIR and the National University of Singapore. China Medical University in Taiwan, Chinese Academy of Sciences, Shanghai University of Traditional Chinese Medicine and Sun Yat-sen University of Medical Science were the major research institutions of AP in China. (4) The top 3 authors with the largest number of papers were all from China. (5) Wong W S F’s team of the National University of Singapore published an academic paper in 2009 with the highest impact factor (21.4) so far, illustrating the molecular mechanism of andrographolide in relieving asthma. With the disclosure of the function of ‘natural antibiotic’ andrographolide in inhibiting COVID-19 protein activity, international scholars have attached great importance to it, and the basic research on the pharmacological effect and high and stable yield of AP will be further deepened.