Changes in serum biomarkers of oxidative stress after treatment for canine leishmaniosis in sick dogs |
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| Institution: | 1. Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Regional Campus of International Excellence ‘Campus Mare Nostrum’, University of Murcia, 30100, Espinardo, Murcia, Spain;2. Department of Animal Medicine and Surgery, Veterinary School, Autonomous University of Barcelona, 08193, Barcelona, Spain;3. Department of Plant Biology (Plant Physiology), Faculty of Biology, University of Murcia, 30100, Espinardo, Murcia, Spain;4. R&D Animal Health Bioiberica SA, Barcelona, Spain;1. Department of Pediatrics, The Children''s Hospital of Philadelphia, Philadelphia, PA;;2. Department of Pathology and Laboratory Medicine and;3. Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC;;4. Howard Hughes Medical Institute and;5. Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children''s Hospital of Philadelphia, Philadelphia, PA; and;6. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;1. Faculty of Veterinary Medicine, University of Belgrade, Bulevar oslobođenja 18, 11000 Belgrade, Serbia;2. Small Animal Private Practice “Petrovac”, Borčanskih žrtava 1914, 92, 11000 Belgrade, Serbia;3. Center for Medical Biochemistry, Clinical Center of Serbia, Višegradska 26, 11000 Belgrade, Serbia;1. Department of Pathology, Faculty of Medicine, University of Niš, Blvd Zorana Djindjica 81, 18000 Niš, Serbia;2. Department of Public Health and Infectious Diseases, “Sapienza” University of Rome, Piazza le Aldo Moro 5, 00185 Rome, Italy;3. Scientific Veterinary Institute Novi Sad, Rumenački put 20, 21000 Novi Sad, Serbia;4. Department of Microbiology and Immunology, Faculty of Medicine, University of Niš, Blvd Zorana Djindjica 81, 18000 Niš, Serbia;5. Center of Microbiology and Parasitology, Public Health Institute Niš, Blvd Zorana Djindjica 50, 18000 Niš, Serbia;1. Vasco da Gama Research Center (CIVG), Department of Veterinary Medicine, Vasco da Gama Universitary School, Av. José R. Sousa Fernandes, 197 Lordemão, 3020-210, Coimbra, Portugal;2. Baixo Vouga Veterinary Hospital, EN1, 355, 3750-742, Águeda, Portugal;3. Animal and Veterinary Research Centre (CECAV), University of Trás-os-Montes and Alto Douro, Quinta de Prados, 5000-801, Vila Real, Portugal;4. Department of Animal Medicine and Surgery, Autonomous University of Barcelona, Campus de la UAB, Plaça Cívica, s/n, 08193 Bellaterra, Barcelona, Spain;5. Interdisciplinary Laboratory of Clinical Analysis Interlab-UMU, University of Murcia, Ed. 16 Campus de Espinardo, 30100 Espinardo, Murcia, Spain;6. Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, R. Marquês de Ávila e Bolama, 6201-001 Covilhã, Portugal;7. Health Sciences Research Center (CICS-UBI), University of Beira Interior, R. Marquês de Ávila e Bolama, 6201-001 Covilhã, Portugal;8. Department of Veterinary Sciences, University of Trás-os-Montes e Alto Douro, Quinta de Prados, 5000-801, Vila Real, Portugal |
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| Abstract: | Canine leishmaniosis (CanL) is a zoonotic disease being endemic in several parts of the world. In this study we investigated the behavior of a panel of biomarkers of oxidative stress in 12 sick dogs naturally infected by CanL before and at days 30 and 180 of a successful therapy with a standard treatment. The assays total oxidant status (TOS), trolox equivalent antioxidant capacity (TEAC), ferric reducing ability of plasma (FRAP), cupric reducing antioxidant capacity (CUPRAC), serum thiol and paraoxonase 1 (PON1) were included in the panel. In addition, correlations between biomarkers of oxidative stress and inflammation (C-reactive protein (CRP) and ferritin) and urinary protein:creatinine ratio (UPC) were calculated. Serum CUPRAC, thiol and PON1 significantly increased after treatment and were negatively correlated with CRP, ferritin and UPC. This study demonstrates that biomarkers of oxidative stress, not previously studied in leishmaniosis such as CUPRAC and thiol, can change after a successful treatment for CanL showing a potential for use in monitoring the treatment of this disease. |
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| Keywords: | Antioxidant Cupric Dogs Ferric Leishmaniosis Thiol |
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