A novel cytotoxic flavonoid glycoside from Physalis angulata. |
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| Authors: | N Ismail M Alam |
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| Affiliation: | College of Pharmacy, University of Houston, 4800 Calhoun, Houston, TX 77204-5515, USA. nargisi@hotmail.com |
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| Abstract: | A new flavonol glycoside, myricetin 3-O-neohesperidoside (1) was isolated from a cytotoxic MeOH extract of the leaves of Physalis angulata. Compound 1 showed remarkable cytotoxicity in vitro against murine leukemia cell line P-388, epidermoid carcinoma of the nasopharynx KB-16 cells, and lung adenocarcinoma A-549 with ED(50) values of 0.048, 0.50 and 0.55 microg ml(-1), respectively. |
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