猪内服和静脉给予多西环素的药代动力学研究 |
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引用本文: | 魏丽娟,贾 兴. 猪内服和静脉给予多西环素的药代动力学研究[J]. 中国兽药杂志, 2017, 51(9): 24-29 |
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作者姓名: | 魏丽娟 贾 兴 |
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作者单位: | 河北远征药业有限公司,河北远征药业有限公司 |
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摘 要: | 建立了超高效液相色谱-串联质谱法测定猪血浆中多西环素的浓度,探讨了猪内服和静脉给予多西环素水溶液后的药代动力学特征。结果表明:猪单次内服10 mg.kg-1体重多西环素饮水剂型水溶液后,MRTlast为12.82±3.34 h,T1/2为11.65±4.80 h,Tmax为4.13±1.89 h,Cmax为0.87±0.48 μg.mL-1,AUClast为11.07±4.19μg.h.mL-1。猪静注10 mg.kg-1体重多西环素水溶液后,AUClast为33.34±8.03μg.h.mL-1,T1/2为5.68±1.32 h,MRTlast为7.98±0.56 h。多西环素饮水剂水溶液的绝对生物利用度为33.2%。猪内服多西环素饮水剂后,具有体内吸收速度较快,达峰时间短,消除较慢,血中平均滞留时间较长等特点。
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关 键 词: | 多西环素饮水剂 超高效液相色谱-串联质谱 药代动力学 猪 |
收稿时间: | 2017-04-13 |
修稿时间: | 2017-08-16 |
Pharmacokinetics of Doxycycline in swine after Oral and Intravenous Administration |
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Affiliation: | Hebei Yuanzhoang Phamaceutical CO,LTD, |
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Abstract: | An UPLC-MS/MS method was established for the detection of concentration of doxycycline in porcine plasma. The pharmacokinetis of oral and intravenous doxycycline were investigated in pig. The results demonstrated that: At a single oral dose of 10 mg ? kg-1 body weight of doxycycline drinking water, MRTlast = 12.82±3.34 h, T1/2 = 11.65±4.80 h, Tmax = 4.13± |
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Keywords: | Doxycycline Drinking Water, UPLC-MS/MS, Pharmacokinetics, Swine |
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