Effect of a Single Injection of Long-acting Progesterone on the First Ovulation in Early and Late Spring Transitional Mares |
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| Authors: | Simon A Staempfli Sarah Clavier Don L Thompson Patrick J Burns Sara K Lyle Angus O McKinnon |
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| Institution: | 1. Equine Health Studies Program, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA;2. Goulburn Valley Equine Hospital, Congupna, Victoria, Australia;3. School of Animal Sciences, Louisiana Agricultural Experiment Station, Louisiana State University Agricultural Center, Baton Rouge, LA;4. BioRelease Technology, Lexington, KY;1. Elm Equine Clinic, 59-61 Midorimachi, Urakawa, Hokkaido 057-0025, Japan;2. NOSAI-Hidaka, 1-17-13 Sakaimachinishi, Urakawa, Hokkaido 057-0034, Japan;3. Hidaka Horse Breeders Association, 2-1-1 Tsukiji, Urakawa, Hokkaido 057-0024, Japan;4. Hidaka Training and Research Center, Japan Racing Association, 535-13 Nishicha, Urakawa, Hokkaido 057-0171, Japan;5. Laboratory of Racing Chemistry, 1731-2 Tsurutamachi, Utsunomiya, Tochigi 320-0851, Japan;6. Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido 080-8555, Japan;1. Department of Veterinary Clinical Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK;2. Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA;1. Laboratório de Biotecnologia e Reprodução Animal (BioRep), Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil;2. Laboratório de Fisiologia Molecular e Integrativa da Reprodução (MINT), Universidade Federal do Pampa (Unipampa), Uruguaiana, Rio Grande do Sul, Brazil;3. Departamento de Zootecnia, Universidade do Estado de Santa Catarina, Chapecó, Santa Catarina, Brazil;4. Instituto Sócio Ambiental e dos Recursos Hídricos, Universidade Federal Rural da Amazônia (UFRA), Belém, Pará, Brazil;5. Instituto da Saúde e Produção Animal, Universidade Federal Rural da Amazônia (UFRA) Belém, Pará, Brazil;6. Historep, Instituto de Biologia, Universidade Federal de Pelotas (UFPEL), Campus da Saúde, Pelotas, Rio Grande do Sul, Brazil;7. Brasil Reprodução Animal e Universidade Iguaçu – UNIG, Iguaçu, Rio de Janeiro, Brazil;8. Departamento de Patologia Animal, Faculdade de Medicina Veterinária, Universidade Federal de Pelotas (UFPEL), Capão do Leão, Rio Grande do Sul, Brazil;9. Departamento de Zootecnia, Faculdade de Agronomia Eliseu Maciel, Universidade Federal de Pelotas (UFPEL), Capão do Leão, Rio Grande do Sul, Brazil;1. School of Agriculture and Food Science, University College Dublin, Belfield, Dublin 4, Ireland;2. School of Electrical, Electronic and Mechanical Engineering, University College Dublin, Belfield, Dublin 4, Ireland;1. School of Agriculture and Food Science, University College Dublin, Belfield, Dublin 4, Ireland;2. School of Electrical, Electronic and Mechanical Engineering, University College Dublin, Belfield, Dublin 4, Ireland |
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| Abstract: | Since 1966, exogenous progestins have been used in equine practice for pregnancy maintenance, estrous suppression, and control of erratic sexual behavior. This study was designed to investigate the use of a new compounded controlled-release progesterone preparation (BioRelease P4 LA 300) in early and late spring transitional mares. In the first experiment, the pharmacodynamic properties of the preparation were studied in five geldings. In the second experiment, the use of a single intramuscular injection (600 mg) was tested in 68 embryo-recipient mares maintained under natural photoperiod in the Southern Hemisphere. Experiment 1 demonstrated elevated serum concentrations of progesterone (>1 ng/mL) for 7.6 ± 2.2 days. In experiment 2, there was no effect of treatment in mares that were treated on September 18, independent of their follicular status at day of treatment (10 to 15 mm; 20 to 25 mm, respectively). When mares with a follicular size of 20 to 25 mm were treated on October 14, significantly more progestin-treated mares (10/12; 83%) ovulated between 10 and 24 days after treatment than untreated controls (3/12; 25%) (P < .05). Additionally, there was a trend in mares treated on October 14 for a shorter treatment to ovulation interval (mean ± SD, 18.6 ± 8.7 days) compared with untreated controls (mean ± SD, 26.7 ± 14.7 days) (P = .07). Administration of one single injection of long-acting progesterone is a simple and effective method of controlling the first ovulation of the season in late transitional mares. |
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