| 1,2-肼二(二硫代甲酸甲酯)的合成及抑菌活性研究 |
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| 引用本文： | 李振华,尹文华,孙云明,王艳丽,丁彩真,杨洪迪,杨青,董风英. 1,2-肼二(二硫代甲酸甲酯)的合成及抑菌活性研究[J]. 山东农业科学, 2012, 44(9): 93-94,97 |
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| 作者姓名： | 李振华 尹文华 孙云明 王艳丽 丁彩真 杨洪迪 杨青 董风英 |
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| 作者单位： | 1. 青岛农业大学化学与药学院,山东青岛,266109
2. 青岛市海泊河污水处理厂,山东青岛,266021 |
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| 基金项目： | 青岛农业大学高层次人才启动基金 |
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| 摘 要： | 以二硫化碳、水合肼、硫酸二甲酯等为原料,合成了1,2-肼二(二硫代甲酸甲酯)。其结构经熔点、红外光谱进行了确证。采用菌丝生长速率法研究了1,2-肼二(二硫代甲酸甲酯)的抑菌活性。结果表明:1,2-肼二(二硫代甲酸甲酯)对葡萄黑痘病菌、辣椒炭疽病菌、苹果腐烂病菌、棉花枯萎病菌和苹果轮纹病菌等5种供试病原菌都有很好的抑制作用,其EC50值均小于20 mg/L。其中对苹果腐烂病菌的抑制作用最强,其EC50值为2.2 mg/L。
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| 关 键 词： | -肼二(二硫代甲酸甲酯) 合成 抑菌活性 |
Study on Synthesis and Antifungal Activity of Dimethyl-1,2-Hydrazine Bis (Dithioformate) |
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| LI Zhen-hua , YIN Wen-hua , SUN Yun-ming , WANG Yan-li , DING Cai-zhen , YANG Hong-di , YANG Qing , DONG Feng-ying. Study on Synthesis and Antifungal Activity of Dimethyl-1,2-Hydrazine Bis (Dithioformate)[J]. Shandong Agricultural Sciences, 2012, 44(9): 93-94,97 |
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| Authors: | LI Zhen-hua YIN Wen-hua SUN Yun-ming WANG Yan-li DING Cai-zhen YANG Hong-di YANG Qing DONG Feng-ying |
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| Affiliation: | 1*(1.College of Chemistry and Pharmaceutical Sciences,Qingdao Agricultural University,Qingdao 266109,China; 2.Qingdao Haibohe Waste Water Treatment Plant,Qingdao 266021,China) |
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| Abstract: | Dimethyl-1,2-hydrazine bis(dithioformate) was synthesized with carbon bisulfide,hydrazine hydrate,dimethyl sulfate and so on.Its structure was characterized by MP and IR and its antifungal activities were studied by mycelia growth rate method.The results showed that it had good inhibition effects on Sphaceloma ampelinum,Colletotrichum capsici,Valsa mali,Fusarium oxysporum f.sp.vasinfectum and Physalospora piricola with the EC50 values less than 20 mg/L.It had the strongest inhibiton effect on Valsa mali with EC50 value as 2.2 mg/L. |
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| Keywords: | Dimethyl-1,2-hydrazine bis(dithioformate) Synthesis Antifungal activity |
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