| 脂质体对鸡新城疫疫苗免疫增强作用的研究 |
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| 引用本文： | 张春杰,朱维正.脂质体对鸡新城疫疫苗免疫增强作用的研究[J].中国兽医学报,1992(3). |
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| 作者姓名： | 张春杰 朱维正 |
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| 作者单位： | 兽医大学传染病教研室
(张春杰)，兽医大学传染病教研室(朱维正) |
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| 摘 要： | 应用薄膜分散法(TFDM)和反相蒸发法(REM)制备了两种脂质体一新城疫(L-ND)疫苗.由REM制备的L-ND疫苗,无论应用于高母源抗体鸡,还是低母源抗体鸡,L-ND疫苗组的HI抗体效价均明显高于单纯疫苗组(P<0.05);在免疫后2～3周内,其ANAE~+淋巴细胞百分数也均高于单纯疫苗组(P<0.05);对高母源抗体鸡的有效免疫期比单纯ND疫苗延长1周,对低母源抗体鸡的有效免疫期延长3周.
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| 关 键 词： | 脂质体 免疫增强剂 鸡新城疫 疫苗 |
Immunoenhancement of Liposomes on Newcastle Disease Vaccine |
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| Zhang Chunjie et al.Immunoenhancement of Liposomes on Newcastle Disease Vaccine[J].Chinese Journal of Veterinary Science,1992(3). |
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| Authors: | Zhang Chunjie |
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| Abstract: | Two kinds of liposome-associated ND (L-ND) vaccines were prepared by thin film dispersed method (TFDM) and reversephase evaporation method (REM) respectively. After morphological identification and determination of entrapment efficiency, a higher entrapping ratio ND vaccine prepared by REM was selected to vaccinate the chickens. The results showed that the titre of haemagglutination inhibition (HI) antibody in L-ND group with high or low levels of maternal antibodies were significantly higher than those of single vaccine group (p<0. 05), and that the percentage of ANAE+ lymphocyte in L-ND group was much higher than that of single group (p<0. 05) within 2-3 weeks after vaccination. The effective immune period in L-ND group was 1-3 weeks longer than that of single vaccine group. |
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| Keywords: | liposome immunopotentiator ND vaccine |
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