Evaluation of a topical treatment, alone and in combination with a detergent, for generalized demodicosis |
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Authors: | S D Folz D D Kratzer L H Nowakowski R D Conklin D L Rector |
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Institution: | The Upjohn Company, Kalamazoo, MI 49001, U.S.A. |
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Abstract: | Thirty dogs (20 treated, 10 controls) with naturally-acquired generalized demodicosis were utilized to evaluate the bio-activity and safety of a liquid concentrate formulation of amitraz, with or without the addition of a nonionic detergent. The detergent was added to the treatment mixture to enhance wetting and thereby reduce the number of treatments required to return diseased animals to a normal state. Three--six miticide treatments were topically applied to dogs at 14-day intervals, at a concentration of 250 parts per million active drug. The liquid concentrate with or without detergent, was equally effective and safe as a dermatotherapy for demodicosis; addition of the nonionic detergent grossly improved the wetting characteristics of the treatment mixture; however, it did not alter the biological activity or the safety of the therapy. |
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