Basic fibroblast growth factor promoting the healing of palatal perforation in rats |
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Authors: | KONG Wei-dong LIN Wei LI Xiao-lan SHEN Li-jia DENG Guo-zheng |
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Institution: | Dept. of Stomotology, First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510632, China |
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Abstract: | AIM: To study the influence of basic fibroblast growth factor(bFGF) on treating ed palatal perforation in rats. METHODS: bFGF was given to the early palatal perforation in rat. The granulation tissues in perforations were grossly and pathologically obserVed. RESULTS: The the of wound healing was significantly in- crease in the bFGF group (P<0.01 ). bFGF could obviously promote the proliferation of the granulation tissues and fibroblasts. The number of AgNORs granules in fibrablasts were 3.73 ±0.52 in the buy group and 2.11 ±0.31 in control group (P < 0.05). CONCLUSION: bFGF could promote the growth of granulation tissues and had a strong promotion on the wound healing in palatal perforation. It was helpful in repairing palatal perforation. |
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Keywords: | Fibroblast growth factor basic Cleft palatal Wound healing |
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